Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease
Ilana Caro, Daniel Western, Shinichi Namba, Na Sun, Shuji Kawaguchi, Yunye He, Masashi Fujita, Gennady Roshchupkin, Tim D’Aoust, Marie-Gabrielle Duperron, Muralidharan Sargurupremraj, Ami Tsuchida, Masaru Koido, Marziehsadat Ahmadi, Chengran Yang, Jigyasha Timsina, Laura Ibanez, Koichi Matsuda, Yutaka Suzuki, Yoshiya Oda, Akinori Kanai, Pouria Jandaghi, Markus Munter, Daniel Auld, Iana Astafeva, Raquel Puerta, Jerome I. Rotter, Bruce M. Psaty, Joshua C. Bis, WT Longstreth, Thierry Couffinhal, Pablo García-González, Vanesa Pytel, Marta Marquié, Amanda Cano, Mercè Boada, Marc Joliot, Mark Lathrop, Quentin Le Grand, Lenore J. Launer, Joanna M. Wardlaw, Myriam Heiman, Agustin Ruiz, Paul M. Matthews, Sudha Seshadri, Myriam Fornage, Hieab Adams, Aniket Mishra, David-Alexandre Trégouët, Yukinori Okada, Manolis Kellis, Philip L. De Jager, Christophe Tzourio, Yoichiro Kamatani, Fumihiko Matsuda, Carlos Cruchaga, Stéphanie Debette
Nature Aging. 2025-11-20
10.1038/s43587-025-01006-w

White matter hyperintensity spatial patterns: Risk factors and clinical correlates
Frauke Beyer, Ami Tsuchida, Aicha Soumaré, Hema Sekhar Reddy Rajula, Aniket Mishra, Fabrice Crivello, Cécile Proust‐Lima, Markus Loeffler, Christophe Tzourio, Philippe Amouyel, Arno Villringer, Markus Scholz, Hélène Jacqmin‐Gadda, Marc Joliot, A. Veronica Witte, Carole Dufouil, Stéphanie Debette
Alzheimer's & Dementia. 2025-04-01
10.1002/alz.70053

SHIVA-CMB: a deep-learning-based robust cerebral microbleed segmentation tool trained on multi-source T2*GRE- and susceptibility-weighted MRI
Ami Tsuchida, Martin Goubet, Philippe Boutinaud, Iana Astafeva, Victor Nozais, Pierre-Yves Hervé, Thomas Tourdias, Stéphanie Debette, Marc Joliot
Sci Rep. 2024-12-28
10.1038/s41598-024-81870-5

Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease
Quentin Le Grand, Ami Tsuchida, Alexandra Koch, Mohammed-Aslam Imtiaz, N. Ahmad Aziz, Chloé Vigneron, Laure Zago, Mark Lathrop, Alexandre Dubrac, Thierry Couffinhal, Fabrice Crivello, Paul M. Matthews, Aniket Mishra, Monique M. B. Breteler, Christophe Tzourio, Stéphanie Debette
Mol Psychiatry. 2024-05-29
10.1038/s41380-024-02604-7

Genetic variants for head size share genes and pathways with cancer
Maria J. Knol, Raymond A. Poot, Tavia E. Evans, Claudia L. Satizabal, Aniket Mishra, Muralidharan Sargurupremraj, Sandra van der Auwera, Marie-Gabrielle Duperron, Xueqiu Jian, Isabel C. Hostettler, Dianne H.K. van Dam-Nolen, Sander Lamballais, Mikolaj A. Pawlak, Cora E. Lewis, Amaia Carrion-Castillo, Theo G.M. van Erp, Céline S. Reinbold, Jean Shin, Markus Scholz, Asta K. Håberg, Anders Kämpe, Gloria H.Y. Li, Reut Avinun, Joshua R. Atkins, Fang-Chi Hsu, Alyssa R. Amod, Max Lam, Ami Tsuchida, Mariël W.A. Teunissen, Nil Aygün, Yash Patel, Dan Liang, Alexa S. Beiser, Frauke Beyer, Joshua C. Bis, Daniel Bos, R. Nick Bryan, Robin Bülow, Svenja Caspers, Gwenaëlle Catheline, Charlotte A.M. Cecil, Shareefa Dalvie, Jean-François Dartigues, Charles DeCarli, Maria Enlund-Cerullo, Judith M. Ford, Barbara Franke, Barry I. Freedman, Nele Friedrich, Melissa J. Green, Simon Haworth, Catherine Helmer, Per Hoffmann, Georg Homuth, M. Kamran Ikram, Clifford R. Jack, Neda Jahanshad, Christiane Jockwitz, Yoichiro Kamatani, Annchen R. Knodt, Shuo Li, Keane Lim, W.T. Longstreth, Fabio Macciardi, Philippe Amouyel, Konstantinos Arfanakis, Benjamin S. Aribisala, Mark E. Bastin, Ganesh Chauhan, Christopher Chen, Ching-Yu Cheng, Philip L. de Jager, Ian J. Deary, Debra A. Fleischman, Rebecca F. Gottesman, Vilmundur Gudnason, Saima Hilal, Edith Hofer, Deborah Janowitz, J. Wouter Jukema, David C.M. Liewald, Lorna M. Lopez, Oscar Lopez, Michelle Luciano, Oliver Martinez, Wiro J. Niessen, Paul Nyquist, Jerome I. Rotter, Tatjana Rundek, Ralph L. Sacco, Helena Schmidt, Henning Tiemeier, Stella Trompet, Jeroen van der Grond, Henry Völzke, Joanna M. Wardlaw, Lisa Yanek, Jingyun Yang, Ingrid Agartz, Saud Alhusaini, Laura Almasy, David Ames, Katrin Amunts, Ole A. Andreassen, Nicola Armstrong, Manon Bernard, John Blangero, Laura M.E. Blanken, Marco P. Boks, Dorret I. Boomsma, Adam M. Brickman, Henry Brodaty, Randy L. Buckner, Jan K. Buitelaar, Dara M. Cannon, Vaughan J. Carr, Stanley V. Catts, M. Mallar Chakravarty, Qiang Chen, Christopher R.K. Ching, Aiden Corvin, Benedicto Crespo-Facorro, Joanne E. Curran, Gareth E. Davies, Eco J.C. de Geus, Greig I. de Zubicaray, Anouk den Braber, Sylvane Desrivières, Allissa Dillman, Srdjan Djurovic, Wayne C. Drevets, Ravi Duggirala, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Iryna O. Fedko, Guillén Fernández, Simon E. Fisher, Tatiana M. Foroud, Tian Ge, Sudheer Giddaluru, David C. Glahn, Aaron L. Goldman, Robert C. Green, Corina U. Greven, Oliver Grimm, Narelle K. Hansell, Catharina A. Hartman, Ryota Hashimoto, Andreas Heinz, Frans Henskens, Derrek P. Hibar, Beng-Choon Ho, Pieter J. Hoekstra, Avram J. Holmes, Martine Hoogman, Jouke-Jan Hottenga, Hilleke E. Hulshoff Pol, Assen Jablensky, Mark Jenkinson, Tianye Jia, Karl-Heinz Jöckel, Erik G. Jönsson, Sungeun Kim, Marieke Klein, Peter Kochunov, John B. Kwok, Stephen M. Lawrie, Stephanie Le Hellard, Hervé Lemaître, Carmel Loughland, Andre F. Marquand, Nicholas G. Martin, Jean-Luc Martinot, Mar Matarin, Daniel H. Mathalon, Karen A. Mather, Venkata S. Mattay, Colm McDonald, Francis J. McMahon, Katie L. McMahon, Rebekah E, McWhirter, Patrizia Mecocci, Ingrid Melle, Andreas Meyer-Lindenberg, Patricia T. Michie, Yuri Milaneschi, Derek W. Morris, Bryan Mowry, Kwangsik Nho, Thomas E. Nichols, Markus N. Nöthen, Rene L. Olvera, Jaap Oosterlaan, Roel A. Ophoff, Massimo Pandolfo, Christos Pantelis, Irene Pappa, Brenda Penninx, G. Bruce Pike, Paul E. Rasser, Miguel E. Rentería, Simone Reppermund, Marcella Rietschel, Shannon L. Risacher, Nina Romanczuk-Seiferth, Emma Jane Rose, Perminder S. Sachdev, Philipp G. Sämann, Andrew J. Saykin, Ulrich Schall, Peter R. Schofield, Sara Schramm, Gunter Schumann, Rodney Scott, Li Shen, Sanjay M. Sisodiya, Hilkka Soininen, Emma Sprooten, Velandai Srikanth, Vidar M. Steen, Lachlan T. Strike, Anbupalam Thalamuthu, Arthur W. Toga, Paul Tooney, Diana Tordesillas-Gutiérrez, Jessica A. Turner, Maria del C. Valdés Hernández, Dennis van der Meer, Nic J.A. Van der Wee, Neeltje E.M. Van Haren, Dennis van 't Ent, Dick J. Veltman, Henrik Walter, Daniel R. Weinberger, Michael W. Weiner, Wei Wen, Lars T. Westlye, Eric Westman, Anderson M. Winkler, Girma Woldehawariat, Margaret J. Wright, Jingqin Wu, Outi Mäkitie, Bernard Mazoyer, Sarah E. Medland, Susumu Miyamoto, Susanne Moebus, Thomas H. Mosley, Ryan Muetzel, Thomas W. Mühleisen, Manabu Nagata, Soichiro Nakahara, Nicholette D. Palmer, Zdenka Pausova, Adrian Preda, Yann Quidé, William R. Reay, Gennady V. Roshchupkin, Reinhold Schmidt, Pamela J. Schreiner, Kazuya Setoh, Chin Yang Shapland, Stephen Sidney, Beate St Pourcain, Jason L. Stein, Yasuharu Tabara, Alexander Teumer, Anne Uhlmann, Aad van der Lugt, Meike W. Vernooij, David J. Werring, B. Gwen Windham, A. Veronica Witte, Katharina Wittfeld, Qiong Yang, Kazumichi Yoshida, Han G. Brunner, Quentin Le Grand, Kang Sim, Dan J. Stein, Donald W. Bowden, Murray J. Cairns, Ahmad R. Hariri, Ching-Lung Cheung, Sture Andersson, Arno Villringer, Tomas Paus, Sven Cichon, Vince D. Calhoun, Fabrice Crivello, Lenore J. Launer, Tonya White, Peter J. Koudstaal, Henry Houlden, Myriam Fornage, Fumihiko Matsuda, Hans J. Grabe, M. Arfan Ikram, Stéphanie Debette, Paul M. Thompson, Sudha Seshadri, Hieab H.H. Adams
Cell Reports Medicine. 2024-05-01
10.1016/j.xcrm.2024.101529

Prediction of dementia risk from multimodal repeated measures: The added value of brain MRI biomarkers
Ariane Bercu, Carole Dufouil, Stéphanie Debette, Marc Joliot, Ami Tsuchida, Catherine Helmer, Anthony Devaux, Vincent Bouteloup, Cécile Proust‐Lima, Hélène Jacqmin‐Gadda
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2024-04-01
10.1002/dad2.12578

Early detection of white matter hyperintensities using SHIVA‐WMH detector
Ami Tsuchida, Philippe Boutinaud, Violaine Verrecchia, Christophe Tzourio, Stéphanie Debette, Marc Joliot
Human Brain Mapping. 2023-12-05
10.1002/hbm.26548

Association of retinal nerve layers thickness and brain imaging in healthy young subjects from the i‐Share‐Bordeaux study
Sara Cristina Lima Rebouças, Fabrice Crivello, Ami Tsuchida, Christophe Tzourio, Cédric Schweitzer, Jean‐François Korobelnik, Cécile Delcourt, Catherine Helmer
Human Brain Mapping. 2023-07-04
10.1002/hbm.26412

Dietary pattern and brain structure among young adults
Aline Thomas, Loïc Labache, Ami Tsuchida, Julie Arsandaux, Laure Zago, Christophe Tzourio, Fabrice Crivello, Cécilia Samieri
Alzheimer's & Dementia. 2023-06-01
10.1002/alz.064049

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
Marie-Gabrielle Duperron, Maria J. Knol, Quentin Le Grand, Tavia E. Evans, Aniket Mishra, Ami Tsuchida, Gennady Roshchupkin, Takahiro Konuma, David-Alexandre Trégouët, Jose Rafael Romero, Stefan Frenzel, Michelle Luciano, Edith Hofer, Mathieu Bourgey, Nicole D. Dueker, Pilar Delgado, Saima Hilal, Rick M. Tankard, Florian Dubost, Jean Shin, Yasaman Saba, Nicola J. Armstrong, Constance Bordes, Mark E. Bastin, Alexa Beiser, Henry Brodaty, Robin Bülow, Caty Carrera, Christopher Chen, Ching-Yu Cheng, Ian J. Deary, Piyush G. Gampawar, Jayandra J. Himali, Jiyang Jiang, Takahisa Kawaguchi, Shuo Li, Melissa Macalli, Pascale Marquis, Zoe Morris, Susana Muñoz Maniega, Susumu Miyamoto, Masakazu Okawa, Matthew Paradise, Pedram Parva, Tatjana Rundek, Muralidharan Sargurupremraj, Sabrina Schilling, Kazuya Setoh, Omar Soukarieh, Yasuharu Tabara, Alexander Teumer, Anbupalam Thalamuthu, Julian N. Trollor, Maria C. Valdés Hernández, Meike W. Vernooij, Uwe Völker, Katharina Wittfeld, Tien Yin Wong, Margaret J. Wright, Junyi Zhang, Wanting Zhao, Yi-Cheng Zhu, Helena Schmidt, Perminder S. Sachdev, Wei Wen, Kazumichi Yoshida, Anne Joutel, Claudia L. Satizabal, Ralph L. Sacco, Guillaume Bourque, Mark Lathrop, Tomas Paus, Israel Fernandez-Cadenas, Qiong Yang, Bernard Mazoyer, Philippe Boutinaud, Yukinori Okada, Hans J. Grabe, Karen A. Mather, Reinhold Schmidt, Marc Joliot, M. Arfan Ikram, Fumihiko Matsuda, Christophe Tzourio, Joanna M. Wardlaw, Sudha Seshadri, Hieab H. H. Adams, Stéphanie Debette,
Nat Med. 2023-04-01
10.1038/s41591-023-02268-w

Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes
Quentin Le Grand, Claudia L. Satizabal, Muralidharan Sargurupremraj, Aniket Mishra, Aicha Soumaré, Alexandre Laurent, Fabrice Crivello, Ami Tsuchida, Jean Shin, Mélissa Macalli, Baljeet Singh, Alexa S. Beiser, Charles DeCarli, Evan Fletcher, Tomas Paus, Mark Lathrop, Hieab H.H. Adams, Joshua C. Bis, Sudha Seshadri, Christophe Tzourio, Bernard Mazoyer, Stéphanie Debette
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2022-06-01
10.1016/j.bpsc.2021.10.011

Novel characterization of the relationship between verbal list‐learning outcomes and hippocampal subfields in healthy adults
Sandrine Cremona, Laure Zago, Emmanuel Mellet, Laurent Petit, Alexandre Laurent, Antonietta Pepe, Ami Tsuchida, Naka Beguedou, Marc Joliot, Christophe Tzourio, Bernard Mazoyer, Fabrice Crivello
Hum Brain Mapp. 2021-08-28
10.1002/hbm.25614

Age-Related Variations in Regional White Matter Volumetry and Microstructure During the Post-adolescence Period: A Cross-Sectional Study of a Cohort of 1,713 University Students
Ami Tsuchida, Alexandre Laurent, Fabrice Crivello, Laurent Petit, Antonietta Pepe, Naka Beguedou, Stephanie Debette, Christophe Tzourio, Bernard Mazoyer
Front. Syst. Neurosci.. 2021-08-03
10.3389/fnsys.2021.692152

Causal Prefrontal Contributions to Stop-Signal Task Performance in Humans
Michael K. Yeung, Ami Tsuchida, Lesley K. Fellows
Journal of Cognitive Neuroscience. 2021-08-01
10.1162/JOCN_A_01652

The MRi-Share database: brain imaging in a cross-sectional cohort of 1870 university students
Ami Tsuchida, Alexandre Laurent, Fabrice Crivello, Laurent Petit, Marc Joliot, Antonietta Pepe, Naka Beguedou, Marie-Fateye Gueye, Violaine Verrecchia, Victor Nozais, Laure Zago, Emmanuel Mellet, Stéphanie Debette, Christophe Tzourio, Bernard Mazoyer
Brain Struct Funct. 2021-07-20
10.1007/s00429-021-02334-4

3D Segmentation of Perivascular Spaces on T1-Weighted 3 Tesla MR Images With a Convolutional Autoencoder and a U-Shaped Neural Network
Philippe Boutinaud, Ami Tsuchida, Alexandre Laurent, Filipa Adonias, Zahra Hanifehlou, Victor Nozais, Violaine Verrecchia, Leonie Lampe, Junyi Zhang, Yi-Cheng Zhu, Christophe Tzourio, Bernard Mazoyer, Marc Joliot
Front. Neuroinform.. 2021-06-18
10.3389/fninf.2021.641600

Prevalence, Severity, and Clinical Management of Brain Incidental Findings in Healthy Young Adults: MRi-Share Cross-Sectional Study
Aïcha Soumaré, Naka Beguedou, Alexandre Laurent, Bruno Brochet, Constance Bordes, Sandy Mournet, Emmanuel Mellet, Edwige Pereira, Clothilde Pollet, Morgane Lachaize, Marie Mougin, Ami Tsuchida, Hugues Loiseau, Thomas Tourdias, Christophe Tzourio, Bernard Mazoyer, Stéphanie Debette
Front. Neurol.. 2021-05-20
10.3389/FNEUR.2021.675244

Cerebral small vessel disease genomics and its implications across the lifespan
Muralidharan Sargurupremraj, , Hideaki Suzuki, Xueqiu Jian, Chloé Sarnowski, Tavia E. Evans, Joshua C. Bis, Gudny Eiriksdottir, Saori Sakaue, Natalie Terzikhan, Mohamad Habes, Wei Zhao, Nicola J. Armstrong, Edith Hofer, Lisa R. Yanek, Saskia P. Hagenaars, Rajan B. Kumar, Erik B. van den Akker, Rebekah E. McWhirter, Stella Trompet, Aniket Mishra, Yasaman Saba, Claudia L. Satizabal, Gregory Beaudet, Laurent Petit, Ami Tsuchida, Laure Zago, Sabrina Schilling, Sigurdur Sigurdsson, Rebecca F. Gottesman, Cora E. Lewis, Neelum T. Aggarwal, Oscar L. Lopez, Jennifer A. Smith, Maria C. Valdés Hernández, Jeroen van der Grond, Margaret J. Wright, Maria J. Knol, Marcus Dörr, Russell J. Thomson, Constance Bordes, Quentin Le Grand, Marie-Gabrielle Duperron, Albert V. Smith, David S. Knopman, Pamela J. Schreiner, Denis A. Evans, Jerome I. Rotter, Alexa S. Beiser, Susana Muñoz Maniega, Marian Beekman, Julian Trollor, David J. Stott, Meike W. Vernooij, Katharina Wittfeld, Wiro J. Niessen, Aicha Soumaré, Eric Boerwinkle, Stephen Sidney, Stephen T. Turner, Gail Davies, Anbupalam Thalamuthu, Uwe Völker, Mark A. van Buchem, R. Nick Bryan, Josée Dupuis, Mark E. Bastin, David Ames, Alexander Teumer, Philippe Amouyel, John B. Kwok, Robin Bülow, Ian J. Deary, Peter R. Schofield, Henry Brodaty, Jiyang Jiang, Yasuharu Tabara, Kazuya Setoh, Susumu Miyamoto, Kazumichi Yoshida, Manabu Nagata, Yoichiro Kamatani, Fumihiko Matsuda, Bruce M. Psaty, David A. Bennett, Philip L. De Jager, Thomas H. Mosley, Perminder S. Sachdev, Reinhold Schmidt, Helen R. Warren, Evangelos Evangelou, David-Alexandre Trégouët, Mohammad A. Ikram, Wei Wen, Charles DeCarli, Velandai K. Srikanth, J. Wouter Jukema, Eline P. Slagboom, Sharon L. R. Kardia, Yukinori Okada, Bernard Mazoyer, Joanna M. Wardlaw, Paul A. Nyquist, Karen A. Mather, Hans J. Grabe, Helena Schmidt, Cornelia M. Van Duijn, Vilmundur Gudnason, William T. Longstreth, Lenore J. Launer, Mark Lathrop, Sudha Seshadri, Christophe Tzourio, Hieab H. Adams, Paul M. Matthews, Myriam Fornage, Stéphanie Debette
Nat Commun. 2020-12-01
10.1038/s41467-020-19111-2

Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study
Grégory Beaudet, Ami Tsuchida, Laurent Petit, Christophe Tzourio, Svenja Caspers, Jan Schreiber, Zdenka Pausova, Yash Patel, Tomas Paus, Reinhold Schmidt, Lukas Pirpamer, Perminder S. Sachdev, Henry Brodaty, Nicole Kochan, Julian Trollor, Wei Wen, Nicola J. Armstrong, Ian J. Deary, Mark E. Bastin, Joanna M. Wardlaw, Susana Munõz Maniega, A. Veronica Witte, Arno Villringer, Marco Duering, Stéphanie Debette, Bernard Mazoyer
Front. Psychiatry. 2020-05-04
10.3389/fpsyt.2020.00342

Material-specific interference control is dissociable and lateralized in human prefrontal cortex
Maiya R. Geddes, Ami Tsuchida, Victoria Ashley, Diane Swick, Lesley K. Fellows
Neuropsychologia. 2014-11-01
10.1016/j.neuropsychologia.2014.09.024

Are core component processes of executive function dissociable within the frontal lobes? Evidence from humans with focal prefrontal damage
Ami Tsuchida, Lesley K. Fellows
Cortex. 2013-07-01
10.1016/j.cortex.2012.10.014

Are You Upset? Distinct Roles for Orbitofrontal and Lateral Prefrontal Cortex in Detecting and Distinguishing Facial Expressions of Emotion
Ami Tsuchida, Lesley K. Fellows
Cerebral Cortex. 2012-01-05
10.1093/cercor/bhr370

Double Dissociation of Stimulus-Value and Action-Value Learning in Humans with Orbitofrontal or Anterior Cingulate Cortex Damage
Nathalie Camille, Ami Tsuchida, Lesley K. Fellows
J. Neurosci.. 2011-10-19
10.1523/jneurosci.3164-11.2011

Computerized testing augments pencil-and-paper tasks in measuring HIV-associated mild cognitive impairment*
L Koski, M-J Brouillette, R Lalonde, B Hello, E Wong, A Tsuchida, LK Fellows
HIV Medicine. 2011-03-13
10.1111/j.1468-1293.2010.00910.x

Beyond Reversal: A Critical Role for Human Orbitofrontal Cortex in Flexible Learning from Probabilistic Feedback
Ami Tsuchida, Bradley B. Doll, Lesley K. Fellows
J. Neurosci.. 2010-12-15
10.1523/jneurosci.1958-10.2010

Lesion Evidence That Two Distinct Regions within Prefrontal Cortex are Critical for n -Back Performance in Humans
Ami Tsuchida, Lesley K. Fellows
Journal of Cognitive Neuroscience. 2009-12-01
10.1162/JOCN.2008.21172

Ventromedial Prefrontal Cortex Lesions Impair Value Updating of Unchosen Stimuli in a Reversal Task
B.B. Doll, A. Tsuchida, L.K. Fellows, M.J. Frank
NeuroImage. 2009-07-01
10.1016/s1053-8119(09)71363-1