Agnès Nadjar

Team: Neuroimmunology of metabolic health and disease (NOMAD)
Team leader / Professor  |  Professor - PhD  |  Université de Bordeaux

I have always been interested in neuroimmune interactions and their modulation by the environment. Today, my team studies how the brain’s immune cells—microglia and meningeal immunity—regulate energy metabolism, with the goal of harnessing these mechanisms to prevent or slow neurodegenerative diseases such as Alzheimer’s, which are accompanied by profound metabolic disturbances.

Publications

Isolation of Hypothalamic Microglia from Freshly Perfused Adult Mouse Brain by Magnetic-Activated Cell Sorting
Evangelia Kyriakidou, Giulia Cutugno, Camille Allard, Agnes Nadjar
JoVE. 2024-09-06

10.3791/66769

Rethinking the role of microglia in obesity
G. Cutugno, E. Kyriakidou, A. Nadjar
Neuropharmacology. 2024-04-01

10.1016/j.neuropharm.2024.109951

Discovery of a new type of neuroimmune interaction in the aged brain's response to energy surfeit
Agnes Nadjar
Brain, Behavior, and Immunity. 2023-03-01

10.1016/j.bbi.2023.03.010

Microglial homeostasis disruption modulates non-rapid eye movement sleep duration and neuronal activity in adult female mice
Katherine Picard, Giorgio Corsi, Fanny Decoeur, Maria Amalia Di Castro, Maude Bordeleau, Marine Persillet, Sophie Layé, Cristina Limatola, Marie-Ève Tremblay, Agnès Nadjar
Brain, Behavior, and Immunity. 2023-01-01

10.1016/j.bbi.2022.09.016

Microglia states and nomenclature: A field at its crossroads
Rosa C. Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, (...) Agnes Nadjar, (...), Susanne A. Wolf, Long-Jun Wu, Tony Wyss-Coray
Neuron. 2022-11-01

10.1016/j.neuron.2022.10.020

Nanoparticles: The new promise for region-specific targeting of microglia
Agnes Nadjar
Matter. 2022-08-01

10.1016/j.matt.2022.06.048

Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia
Noelia Rodríguez-Iglesias, Agnès Nadjar, Amanda Sierra, Jorge Valero
Int. J. Mol. Sci.. 2022-03-21

10.3390/ijms23063399

N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice.
Fanny Decoeur, Katherine Picard, Marie-Kim St-Pierre, Andrew D. Greenhalgh, Jean-Christophe Delpech, Alexandra Sere, Sophie Layé, Marie-Eve Tremblay, Agnès Nadjar
Front. Cell. Neurosci.. 2022-02-10

10.3389/fncel.2022.802411

Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner
Julia De Meij, Zain Alfanek, Lydie Morel, Fanny Decoeur, Quentin Leyrolle, Katherine Picard, Micael Carrier, Agnes Aubert, Alexandra Séré, Céline Lucas, Gerald Laforest, Jean-Christophe Helbling, Marie-Eve Tremblay, Daniela Cota, Marie-Pierre Moisan, Giovanni Marsicano, Sophie Layé, Agnès Nadjar
Cannabis and Cannabinoid Research. 2021-12-01

10.1089/can.2020.0170

Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis
Julien Bourel, Vincent Planche, Nadège Dubourdieu, Aymeric Oliveira, Alexandra Séré, Eva-Gunnel Ducourneau, Marion Tible, Marlène Maitre, Thierry Lesté-Lasserre, Agnes Nadjar, Aline Desmedt, Philippe Ciofi, Stéphane H. Oliet, Aude Panatier, Thomas Tourdias
Neurobiology of Disease. 2021-12-01

10.1016/j.nbd.2021.105533

N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development
Quentin Leyrolle, Fanny Decoeur, Cyril Dejean, Galadriel Brière, Stephane Leon, Ioannis Bakoyiannis, Emilie Baroux, Tony‐Lee Sterley, Clémentine Bosch‐Bouju, Lydie Morel, Camille Amadieu, Cynthia Lecours, Marie‐Kim St‐Pierre, Maude Bordeleau, Véronique De Smedt‐Peyrusse, Alexandran Séré, Leslie Schwendimann, Stephane Grégoire, Lionel Bretillon, Niyazi Acar, Corinne Joffre, Guillaume Ferreira, Raluca Uricaru, Patricia Thebault, Pierre Gressens, Marie‐Eve Tremblay, Sophie Layé, Agnes Nadjar
Glia. 2021-09-14

10.1002/glia.24088

Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle
Giorgio Corsi, Katherine Picard, Maria Amalia Castro, Stefano Garofalo, Federico Tucci, Giuseppina Chece, Claudio Percio, Maria Teresa Golia, Marcello Raspa, Ferdinando Scavizzi, Fanny Decoeur, Clotilde Lauro, Mara Rigamonti, Fabio Iannello, Davide Antonio Ragozzino, Eleonora Russo, Giovanni Bernardini, Agnès Nadjar, Marie Eve Tremblay, Claudio Babiloni, Laura Maggi, Cristina Limatola
Glia. 2021-09-06

10.1002/glia.24090

Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death?
Stéphane Léon, Agnès Nadjar, Carmelo Quarta
IJMS. 2021-05-15

10.3390/ijms22105243

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain.
C. Madore, Q. Leyrolle, L. Morel, M. Rossitto, A. D. Greenhalgh, J. C. Delpech, M. Martinat, C. Bosch-Bouju, J. Bourel, B. Rani, C. Lacabanne, A. Thomazeau, K. E. Hopperton, S. Beccari, A. Sere, A. Aubert, V. De Smedt-Peyrusse, C. Lecours, K. Bisht, L. Fourgeaud, S. Gregoire, L. Bretillon, N. Acar, N. J. Grant, J. Badaut, P. Gressens, A. Sierra, O. Butovsky, M. E. Tremblay, R. P. Bazinet, C. Joffre, A. Nadjar, S. Layé
Nat Commun. 2020-11-30

10.1038/s41467-020-19861-z

Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime
Q. Leyrolle, F. Decoeur, G. Briere, C. Amadieu, A. R. A. A. Quadros, I. Voytyuk, C. Lacabanne, A. Benmamar-Badel, J. Bourel, A. Aubert, A. Sere, F. Chain, L. Schwendimann, B. Matrot, T. Bourgeois, S. Grégoire, J. G. Leblanc, A. De Moreno De Leblanc, P. Langella, G. R. Fernandes, L. Bretillon, C. Joffre, R. Uricaru, P. Thebault, P. Gressens, J. M. Chatel, S. Layé, A. Nadjar
Neuropsychopharmacol.. 2020-08-11

10.1038/s41386-020-00793-7

Role of Glia in the Regulation of Sleep in Health and Disease.
Stefano Garofalo, Katherine Picard, Cristina Limatola, Agnès Nadjar, Olivier Pascual, Marie‐Ève Tremblay
Comprehensive Physiology. 2020-03-12

10.1002/cphy.c190022

Direct and indirect effects of lipids on microglia function
Q. Leyrolle, S. Layé, A. Nadjar
Neuroscience Letters. 2019-08-01

10.1016/j.neulet.2019.134348

Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression
Richard P. Bazinet, Adam H. Metherel, Chuck T. Chen, Saame Raza Shaikh, Agnes Nadjar, Corinne Joffre, Sophie Layé
Brain, Behavior, and Immunity. 2019-07-01

10.1016/j.bbi.2019.07.001

Dietary N-3 PUFA deficiency affects sleep-wake activity in basal condition and in response to an inflammatory challenge in mice
F. Decoeur, A. Benmamar-Badel, Q. Leyrolle, M. Persillet, S. Layé, A. Nadjar
Brain, Behavior, and Immunity. 2019-05-01

10.1016/j.bbi.2019.05.016

Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain
C. Rey, J.C. Delpech, C. Madore, A. Nadjar, A.D. Greenhalgh, C. Amadieu, A. Aubert, V. Pallet, C. Vaysse, S. Layé, C. Joffre
Brain, Behavior, and Immunity. 2019-02-01

10.1016/j.bbi.2018.07.025

Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation.
V.F. Labrousse, Q. Leyrolle, C. Amadieu, A. Aubert, A Sere, E. Coutureau, S. Grégoire, L. Bretillon, V. Pallet, P. Gressens, C. Joffre, A. Nadjar, S. Layé
Brain, Behavior, and Immunity. 2018-10-01

10.1016/j.bbi.2018.06.004

Role of metabolic programming in the modulation of microglia phagocytosis by lipids.
A. Nadjar
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018-08-01

Role of metabolic programming in the modulation of microglia phagocytosis by lipids.
A. Nadjar
Prostaglandins, Leukotrienes and Essential Fatty Acids.

10.1016/j.plefa.2018.07.006

Maternal n-3 polyunsaturated fatty acid dietary supply modulates microglia lipid content in the offspring
Charlotte Rey, Agnès Nadjar, Florent Joffre, Camille Amadieu, Agnès Aubert, Carole Vaysse, Véronique Pallet, Sophie Layé, Corinne Joffre
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018-06-01

10.1016/j.plefa.2018.04.003

Antiinflammatory Properties of Dietary n-3 Polyunsaturated Fatty Acids Protect Against Cognitive Decline in Aging and Neurodegenerative Diseases
Agnes Nadjar, Quentin Leyrolle, Corinne Joffre, Sophie Layé
Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases. 2018-01-01

Antiinflammatory Properties of Dietary n-3 Polyunsaturated Fatty Acids Protect Against Cognitive Decline in Aging and Neurodegenerative Diseases
Agnes Nadjar, Quentin Leyrolle, Corinne Joffre, Sophie Layé
Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases.

10.1016/b978-0-12-811959-4.00024-9

Anti-inflammatory effects of omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology
Sophie Layé, Agnès Nadjar, Corinne Joffre, Richard P. Bazinet
Pharmacol Rev. 2017-12-07

10.1124/pr.117.014092

Bioactive lipids as new class of microglial modulators: When nutrition meets neuroimunology
A. Nadjar, Q. Leyrolle, C. Joffre, S. Laye
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017-10-01

10.1016/j.pnpbp.2016.07.004

Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders
Agnes Nadjar, Henna-Kaisa M. Wigren, Marie-Eve Tremblay
Front. Cell. Neurosci.. 2017-08-30

10.3389/fncel.2017.00250

Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders
Agnes Nadjar, Henna-Kaisa M. Wigren, Marie-Eve Tremblay
Front. Cell. Neurosci..

10.3389/fncel.2017.00250

Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation.
Caroline André, Omar Guzman-Quevedo, Charlotte Rey, Julie Rémus-Borel, Samantha Clark, Ashley Castellanos-Jankiewicz, Elodie Ladeveze, Thierry Leste-Lasserre, Agnes Nadjar, Djoher Nora Abrous, Sophie Laye, Daniela Cota
Diabetes. 2016-11-30

10.2337/db16-0586

Modulation of brain PUFA content in different experimental models of mice
Corinne Joffre, Stéphane Grégoire, Véronique De Smedt, Niyazi Acar, Lionel Bretillon, Agnès Nadjar, Sophie Layé
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-11-01

10.1016/j.plefa.2016.09.003

Enriched dairy fat matrix diet prevents early life lipopolysaccharide-induced spatial memory impairment at adulthood
A.L. Dinel, C. Rey, C. Baudry, C. Fressange-Mazda, P. Le Ruyet, A. Nadjar, P. Pallet, C. Joffre, S. Layé
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-10-01

10.1016/j.plefa.2016.08.013

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra
PLoS Biol. 2016-09-20

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.

PLoS Biol. 2016-09-20

10.1371/journal.pbio.1002554

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra
PLoS Biol.

10.1371/journal.pbio.1002554

Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro
C. Rey, A. Nadjar, B. Buaud, C. Vaysse, A. Aubert, V. Pallet, S. Layé, C. Joffre
Brain, Behavior, and Immunity. 2016-07-01

10.1016/j.bbi.2015.12.013

Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra
PLoS Biol. 2016-05-26

10.1371/journal.pbio.1002466

N-3 PUFAs and neuroinflammatory processes in cognitive disorders
Quentin Leyrolle, Sophie Layé, Agnès Nadjar
OCL. 2016-01-01

10.1051/ocl/2015064

Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota
Charlotte Madore, Quentin Leyrolle, Chloé Lacabanne, Anouk Benmamar-Badel, Corinne Joffre, Agnes Nadjar, Sophie Layé
Neural Plasticity. 2016-01-01

10.1155/2016/3597209

Role of n-3 PUFAs in inflammation via resolvin biosynthesis
Corinne Joffre, Charlotte Rey, Agnès Nadjar, Sophie Layé
OCL. 2015-12-18

10.1051/ocl/2015062

Microglia in neuronal plasticity: Influence of stress
Jean-Christophe Delpech, Charlotte Madore, Agnes Nadjar, Corinne Joffre, Eric S. Wohleb, Sophie Layé
Neuropharmacology. 2015-09-01

10.1016/j.neuropharm.2014.12.034

N-3 polyunsaturated fatty acid and neuroinflammation in aging and Alzheimer’s disease
Sophie Layé, Charlotte Madore, Isabelle St-Amour, Jean-Christophe Delpech, Corinne Joffre, Agnès Nadjar, Frédéric Calon
NUA. 2015-05-21

N-3 polyunsaturated fatty acid and neuroinflammation in aging and Alzheimer’s disease
Sophie Layé, Charlotte Madore, Isabelle St-Amour, Jean-Christophe Delpech, Corinne Joffre, Agnès Nadjar, Frédéric Calon
NUA.

10.3233/nua-150049

Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment
Jean-Christophe Delpech, Aurore Thomazeau, Charlotte Madore, Clementine Bosch-Bouju, Thomas Larrieu, Chloe Lacabanne, Julie Remus-Borel, Agnès Aubert, Corinne Joffre, Agnès Nadjar, Sophie Layé
Neuropsychopharmacol. 2015-05-07

10.1038/npp.2015.127

Microglial Activation Enhances Associative Taste Memory through Purinergic Modulation of Glutamatergic Neurotransmission
J.-C. Delpech, N. Saucisse, S. L. Parkes, C. Lacabanne, A. Aubert, F. Casenave, E. Coutureau, N. Sans, S. Laye, G. Ferreira, A. Nadjar
Journal of Neuroscience. 2015-02-18

10.1523/jneurosci.3028-14.2015

Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes
Charlotte Madore, Agnès Nadjar, Jean-Christophe Delpech, A. Sere, A. Aubert, Céline Portal, Corinne Joffre, Sophie Layé
Brain, Behavior, and Immunity. 2014-10-01

10.1016/j.bbi.2014.03.021

Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation
Jean-Christophe Delpech, Charlotte Madore, Corinne Joffre, Agnès Aubert, Jing Xuan Kang, Agnès Nadjar, Sophie Layé
Neuropsychopharmacol. 2014-08-05

10.1038/npp.2014.196

N-3 LCPUFA improves cognition: The young, the old and the sick
C. Joffre, A. Nadjar, M. Lebbadi, F. Calon, S. Laye
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2014-07-01

10.1016/j.plefa.2014.05.001

Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging
Julie Sauvant, Jean-Christophe Delpech, Karine Palin, Nadia De Mota, Jennifer Dudit, Agnès Aubert, Hélène Orcel, Pascale Roux, Sophie Layé, Françoise Moos, Catherine Llorens-Cortes, Agnès Nadjar
PLoS ONE. 2014-02-05

10.1371/journal.pone.0087421

N-3 polyunsaturated fatty acid and neuroinflammation in aging: Role in cognition
Sophie Layé, Charlotte Madore, Jean-Christophe Delpech, Corinne Joffre, Agnès Nadjar
Pharma-Nutrition. 2014-01-01

10.1007/978-3-319-06151-1_6

Early morphofunctional plasticity of microglia in response to acute lipopolysaccharide
C. Madore, C. Joffre, J.C. Delpech, V. De Smedt-Peyrusse, A. Aubert, L. Coste, S. Layé, A. Nadjar
Brain, Behavior, and Immunity. 2013-11-01

10.1016/j.bbi.2013.08.008

Astrocyte-derived adenosine modulates increased sleep pressure during inflammatory response
Agnes Nadjar, Tamara Blutstein, Agnes Aubert, Sophie Laye, Philip G. Haydon
Glia. 2013-02-04

10.1002/glia.22465

Short-term long chain Omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice
Virginie F. Labrousse, Agnès Nadjar, Corinne Joffre, Laurence Costes, Agnès Aubert, Stéphane Grégoire, Lionel Bretillon, Sophie Layé
PLoS ONE. 2012-05-25

10.1371/journal.pone.0036861

Evolution of the dynamic properties of the cortex-basal ganglia network after dopaminergic depletion in rats
Cyril Dejean, Agnes Nadjar, Catherine Le Moine, Bernard Bioulac, Christian E. Gross, Thomas Boraud
Neurobiology of Disease. 2012-05-01

10.1016/j.nbd.2012.02.004

Neuroinflammation and aging: Influence of dietary n-3 polyunsaturated fatty acid
Sophie Layé, Jean-Christophe Delpech, Véronique De Smedt-Peyrusse, Corinne Joffre, Thomas Larrieu, Charlotte Madore, Agnès Nadjar and Lucile Capuron
OCL. 2011-11-15

10.1684/ocl.2011.0412

Brain cyclooxygenase-2 mediates interleukin-1-induced cellular activation in preoptic and arcuate hypothalamus, but not sickness symptoms.
Agnès Nadjar, Julie Sauvant, Chantal Combe, Patricia Parnet, Jan Pieter Konsman
Neurobiology of Disease. 2010-09-01

10.1016/j.nbd.2010.05.005

IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP.
Agnès Nadjar, Olivier Berton, Shuhong Guo, Patricia Leneuve, Sandra Dovero, Elsa Diguet, François Tison, Baolu Zhao, Martin Holzenberger, Erwan Bezard
Neurobiology of Aging. 2009-12-01

10.1016/j.neurobiolaging.2008.02.009

High frequency stimulation of the entopeduncular nucleus sets the cortico-basal ganglia network to a new functional state in the dystonic hamster.
René Reese, Giselle Charron, Agnès Nadjar, Incarnation Aubert, Marie-Laure Thiolat, Melanie Hamann, Angelika Richter, Erwan Bezard, Wassilios G Meissner
Neurobiology of Disease. 2009-09-01

10.1016/j.nbd.2009.05.022

Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in rats
Karine Palin, Marie L. Moreau, Julie Sauvant, Hélène Orcel, Agnès Nadjar, Anne Duvoid-Guillou, Jennifer Dudit, Alain Rabié, Françoise Moos
American Journal of Physiology-Endocrinology and Metabolism. 2009-06-01

Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in rats
Karine Palin, Marie L. Moreau, Julie Sauvant, Hélène Orcel, Agnès Nadjar, Anne Duvoid-Guillou, Jennifer Dudit, Alain Rabié, Françoise Moos
American Journal of Physiology-Endocrinology and Metabolism.

10.1152/ajpendo.90489.2008

Priming for l-dopa-induced dyskinesia in Parkinson's disease: a feature inherent to the treatment or the disease?
Agnès Nadjar, Charles R. Gerfen, Erwan Bezard
Progress in Neurobiology. 2009-01-01

10.1016/j.pneurobio.2008.09.013

The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor lovastatin reduces severity of L-DOPA-induced abnormal involuntary movements in experimental Parkinson's disease.
S. Schuster, A. Nadjar, J. T. Guo, Q. Li, C. Ittrich, B. Hengerer, E. Bezard
Journal of Neuroscience. 2008-04-23

10.1523/jneurosci.4720-07.2008

Subthalamic stimulation increases striatal tyrosine hydroxylase phosphorylation
Rene Reese, Christine Winter, Agnes Nadjar, Daniel Harnack, Rudolf Morgenstern, Andreas Kupsch, Erwan Bezard, Wassilios Meissner
NeuroReport. 2008-01-01

10.1097/WNR.0b013e3282f417b4

RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson's disease.
S. J. Gold, C. V. Hoang, B. W. Potts, G. Porras, E. Pioli, K. W. Kim, A. Nadjar, C. Qin, G. J. LaHoste, Q. Li, B. H. Bioulac, J. L. Waugh, E. Gurevich, R. L. Neve, E. Bezard
Journal of Neuroscience. 2007-12-26

10.1523/jneurosci.4223-07.2007

Shaping of motor responses by incentive values through the basal ganglia.
B. Pasquereau, A. Nadjar, D. Arkadir, E. Bezard, M. Goillandeau, B. Bioulac, C. E. Gross, T. Boraud
Journal of Neuroscience. 2007-01-31

10.1523/jneurosci.3745-06.2007

Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia.
Nadjar A, Brotchie JM, Guigoni C, Li Q, Zhou SB, Wang GJ, Ravenscroft P, Georges F, Crossman AR, Bezard E.
Journal of Neuroscience. 2006-08-23

10.1523/jneurosci.2582-06.2006

NF¿B Activates in vivo the Synthesis of Inducible Cox-2 in the Brain
Agnès Nadjar, Viviane Tridon, Michael J May, Sankar Ghosh, Robert Dantzer, Thierry Amédée, Patricia Parnet
J Cereb Blood Flow Metab. 2005-08-01

10.1038/sj.jcbfm.9600106

Inactivation of the Cerebral NFκB Pathway Inhibits Interleukin-1β-Induced Sickness Behavior and c-Fos Expression in Various Brain Nuclei
Agnès Nadjar, Rose-Marie Bluthé, Michael J May, Robert Dantzer, Patricia Parnet
Neuropsychopharmacol. 2005-05-18

Inactivation of the Cerebral NFκB Pathway Inhibits Interleukin-1β-Induced Sickness Behavior and c-Fos Expression in Various Brain Nuclei
Agnès Nadjar, Rose-Marie Bluthé, Michael J May, Robert Dantzer, Patricia Parnet
Neuropsychopharmacol.

10.1038/sj.npp.1300755

Inactivation of the Cerebral NF¿B Pathway Inhibits Interleukin-1ß-Induced Sickness Behavior and c-Fos Expression in Various Brain Nuclei
Agnès Nadjar, Rose-Marie Bluthé, Michael J May, Robert Dantzer, Patricia Parnet
Neuropsychopharmacol. 2005-05-18

10.1038/sj.npp.1300755

NFκB Activates in vivo the Synthesis of Inducible Cox-2 in the Brain
Agnès Nadjar, Viviane Tridon, Michael J May, Sankar Ghosh, Robert Dantzer, Thierry Amédée, Patricia Parnet
J Cereb Blood Flow Metab. 2005-03-09

Signaling pathways of interleukin-1 actions in the brain: anatomical distribution of phospho-ERK1/2 in the brain of rat treated systemically with interleukin-1beta.
A. Nadjar, C. Combe, P. Busquet, R. Dantzer, P. Parnet
Neuroscience. 2005-01-01

1104537600

Nuclear factor κB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouse
Agnès Nadjar, Chantal Combe, Sophie Layé, Viviane Tridon, Robert Dantzer, Thierry Amédée, Patricia Parnet
Journal of Neurochemistry. 2004-02-04

10.1046/j.1471-4159.2003.02097.x

Book review: Interleukin protocols, methods in molecular medicine, vol. 70
Agnès Nadjar, Robert Dantzer
Psychoneuroendocrinology. 2003-04-01

10.1016/s0306-4530(02)00071-9