Alpha-synuclein-induced nigrostriatal degeneration and pramipexole treatment disrupt frontostriatal plasticity
Sarah Chevalier, Mélina Decourt, Maureen Francheteau, François Nicol, Anaïs Balbous, Pierre-Olivier Fernagut, Marianne Benoit-Marand
npj Parkinson's Disease. 2024-09-09
10.1038/s41531-024-00781-4

Nigral ATP13A2 depletion induces Parkinson’s disease-related neurodegeneration in a pilot study in non-human primates
Joanna Sikora, Sandra Dovero, Rémi Kinet, Marie-Laure Arotcarena, Sylvain Bohic, Erwan Bezard, Pierre-Olivier Fernagut, Benjamin Dehay
npj Parkinsons Dis.. 2024-08-01
10.1038/s41531-024-00757-4

Dysfunction of striatal parvalbumin interneurons drives motor stereotypies in Cntnap2−/− mouse model of autism spectrum disorders
Mathieu Thabault, Cloé Fernandes-Gomes, Anne-Lise Huot, Maureen Francheteau, Anaïs Balbous-Gautier, Pierre-Olivier Fernagut, Laurie Galvan
PNAS Nexus. 2024-03-28
10.1093/pnasnexus/pgae132

Recent Advances in Clinical Trials in Multiple System Atrophy
David Bendetowicz, Margherita Fabbri, Federico Sirna, Pierre-Olivier Fernagut, Alexandra Foubert-Samier, Tiphaine Saulnier, Anne Pavy Le Traon, Cécile Proust-Lima, Olivier Rascol, Wassilios G. Meissner
Curr Neurol Neurosci Rep. 2024-02-28
10.1007/s11910-024-01335-0

GRK2‐ Targeted Knockdown as Therapy for Multiple System Atrophy
Miguel Lopez‐Cuina, Paul Guérin, Nathalie Dutheil, Christelle Martin, Thierry Leste Lasserre, Pierre‐Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard
Movement Disorders. 2023-04-24
10.1002/mds.29422

Premorbid performances determine the deleterious effects of nigrostriatal degeneration and pramipexole on behavioural flexibility
Mélina Decourt, Eric Balado, Maureen Francheteau, Marcello Solinas, Marianne Benoît-Marand, Pierre-Olivier Fernagut
npj Parkinson's Disease. 2023-03-01
10.1038/s41531-023-00475-3

A metabolic biomarker predicts Parkinson’s disease at the early stages in patients and animal models
David Mallet, Thibault Dufourd, Mélina Decourt, Carole Carcenac, Paola Bossù, Laure Verlin, Pierre-Olivier Fernagut, Marianne Benoit-Marand, Gianfranco Spalletta, Emmanuel L. Barbier, Sebastien Carnicella, Véronique Sgambato, Florence Fauvelle, Sabrina Boulet
Journal of Clinical Investigation. 2022-02-15
10.1172/jci146400

Impaired brain insulin signalling in Parkinson’s disease
Fares Bassil, Anna Delamarre, Marie‐Helene Canron, Nathalie Dutheil, Anne Vital, Marie‐Laure Négrier‐Leibreich, Erwan Bezard, Pierre‐Olivier Fernagut, Wassilios G. Meissner
Neuropathol Appl Neurobiol. 2021-08-17
10.1111/nan.12760

Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA–induced dyskinesia
Elva Fridjonsdottir, Reza Shariatgorji, Anna Nilsson, Theodosia Vallianatou, Luke R. Odell, Luke S. Schembri, Per Svenningsson, Pierre-Olivier Fernagut, Alan R. Crossman, Erwan Bezard, Per E. Andrén
Sci. Adv.. 2021-01-01
10.1126/sciadv.abe5948

L‐DOPA regulates α‐synuclein accumulation in experimental parkinsonism
Marc Deffains, Marie‐Hélène Canron, Margaux Teil, Qin Li, Benjamin Dehay, Erwan Bezard, Pierre‐Olivier Fernagut
Neuropathol Appl Neurobiol. 2020-12-04
10.1111/nan.12678

Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy
Miguel Lopez-Cuina, Paul A. Guerin, Marie-Hélène Canron, Anna Delamarre, Benjamin Dehay, Erwan Bezard, Wassilios G. Meissner, Pierre-Olivier Fernagut
Mov Disord. 2020-04-14
10.1002/mds.28034

Multiple System Atrophy: Recent Developments and Future Perspectives
Wassilios G. Meissner, Pierre‐Olivier Fernagut, Benjamin Dehay, Patrice Péran, Anne Pavy‐Le Traon, Alexandra Foubert‐Samier, Miguel Lopez Cuina, Erwan Bezard, François Tison, Olivier Rascol
Mov Disord. 2019-11-06
10.1002/mds.27894

Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
Marie-Laure Arotcarena, Mathieu Bourdenx, Nathalie Dutheil, Marie-Laure Thiolat, Evelyne Doudnikoff, Sandra Dovero, Andrea Ballabio, Pierre-Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard, Benjamin Dehay
JCI Insight. 2019-08-22
10.1172/jci.insight.129719

Dopamine and eating behavior disorders in Parkinson's disease: A complex recipe
Pierre‐Olivier Fernagut
Movement Disorders. 2019-06-01
10.1002/mds.27703

Sex-dependent behavioral deficits and neuropathology in a maternal immune activation model of autism
Obelia Haida, Tareq Al Sagheer, Anais Balbous, Maureen Francheteau, Emmanuel Matas, Federico Soria, Pierre Olivier Fernagut, Mohamed Jaber
Transl Psychiatry. 2019-03-28
10.1038/s41398-019-0457-y

Dopamine and addiction: what have we learned from 40 years of research
Marcello Solinas, Pauline Belujon, Pierre Olivier Fernagut, Mohamed Jaber, Nathalie Thiriet
Journal of Neural Transmission. 2018-12-19
10.1007/s00702-018-1957-2

Deep brain stimulation does not enhance neuroinflammation in multiple system atrophy
Miguel Lopez-Cuina, Pierre-Olivier Fernagut, Marie-Hélène Canron, Anne Vital, Béatrice Lannes, André Maues De Paula, Nathalie Streichenberger, Dominique Guehl, Philippe Damier, Alexandre Eusebio, Jean-Luc Houeto, François Tison, Christine Tranchant, François Viallet, Tatiana Witjas, Stéphane Thobois, Wassilios G. Meissner
Neurobiology of Disease. 2018-10-01
10.1016/j.nbd.2018.07.016

Impulse control disorders in Parkinson’s disease
Ana Marques, Franck Durif, Pierre-Olivier Fernagut
Journal of Neural Transmission. 2018-03-07
10.1007/s00702-018-1870-8

Multi-facetted impulsivity following nigral degeneration and dopamine replacement therapy.
Michel Engeln, Solène Ansquer, Emilie Dugast, Erwan Bezard, David Belin, Pierre-Olivier Fernagut
Neuropharmacology. 2016-10-01
10.1016/j.neuropharm.2016.05.013

Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.
Fares Bassil, Pierre-Olivier Fernagut, Erwan Bezard, Alain Pruvost, Thierry Leste-Lasserre, Quyen Q. Hoang, Dagmar Ringe, Gregory A. Petsko, Wassilios G. Meissner
Proc Natl Acad Sci USA. 2016-08-01
10.1073/pnas.1609291113

Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease.
Ludovico Arcuri, Riccardo Viaro, Simone Bido, Francesco Longo, Mariangela Calcagno, Pierre-Olivier Fernagut, Nurulain T. Zaveri, Girolamo Calò, Erwan Bezard, Michele Morari
Neurobiology of Disease. 2016-05-01
10.1016/j.nbd.2016.01.016

Inhibiting Lateral Habenula Improves L-DOPA-Induced Dyskinesia.
Matthieu F. Bastide, Brice de la Crompe, Evelyne Doudnikoff, Pierre-Olivier Fernagut, Christian E. Gross, Nicolas Mallet, Thomas Boraud, Erwan Bézard
Biological Psychiatry. 2016-03-01
10.1016/j.biopsych.2014.08.022

Selective Inactivation of Striatal FosB/ΔFosB-Expressing Neurons Alleviates L-DOPA-Induced Dyskinesia.
Michel Engeln, Matthieu F. Bastide, Estelle Toulmé, Benjamin Dehay, Mathieu Bourdenx, Evelyne Doudnikoff, Qin Li, Christian E. Gross, Eric Boué-Grabot, Antonio Pisani, Erwan Bezard, Pierre-Olivier Fernagut
Biological Psychiatry. 2016-03-01
10.1016/j.biopsych.2014.07.007

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.
Matthieu F. Bastide, Wassilios G. Meissner, Barbara Picconi, Stefania Fasano, Pierre-Olivier Fernagut, Michael Feyder, Veronica Francardo, Cristina Alcacer, Yunmin Ding, Riccardo Brambilla, Gilberto Fisone, A. Jon Stoessl, Mathieu Bourdenx, Michel Engeln, Sylvia Navailles, Philippe De Deurwaerdère, Wai Kin D. Ko, Nicola Simola, Micaela Morelli, Laurent Groc, Maria-Cruz Rodriguez, Eugenia V. Gurevich, Maryka Quik, Michele Morari, Manuela Mellone, Fabrizio Gardoni, Elisabetta Tronci, Dominique Guehl, François Tison, Alan R. Crossman, Un Jung Kang, Kathy Steece-Collier, Susan Fox, Manolo Carta, M. Angela Cenci, Erwan Bézard
Progress in Neurobiology. 2015-09-01
10.1016/j.pneurobio.2015.07.002

Region-Specific Alterations of Matrix Metalloproteinase Activity in Multiple System Atrophy
Fares Bassil, Arnaud Monvoisin, Marie-Helene Canron, Anne Vital, Wassilios G. Meissner, François Tison, Pierre-Olivier Fernagut
Mov Disord.. 2015-08-11
10.1002/mds.26329

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.
Mathieu Bourdenx, Sandra Dovero, Michel Engeln, Simone Bido, Matthieu F. Bastide, Nathalie Dutheil, Isabel Vollenweider, Laetitia Baud, Camille Piron, Virginie Grouthier, Thomas Boraud, Grégory Porras, Qin Li, Veerle Baekelandt, Dieter Scheller, Anne Michel, Pierre-Olivier Fernagut, François Georges, Grégoire Courtine, Erwan Bezard, Benjamin Dehay
acta neuropathol commun. 2015-07-25
10.1186/s40478-015-0222-2

Current Concepts in the Treatment of Multiple System Atrophy
Santiago Perez-Lloret, Olivier Flabeau, Pierre-Olivier Fernagut, Anne Pavy-Le Traon, María Verónica Rey, Alexandra Foubert-Samier, Francois Tison, Olivier Rascol, Wassilios G. Meissner
Mov Disord Clin Pract. 2015-02-02
10.1002/mdc3.12145

Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?
Fares Bassil, Pierre-Olivier Fernagut, Erwan Bezard, Wassilios G. Meissner
Progress in Neurobiology. 2014-07-01
10.1016/j.pneurobio.2014.02.005

Multiple system atrophy: a prototypical synucleinopathy for disease-modifying therapeutic strategies.
Pierre-Olivier Fernagut, Benjamin Dehay, Aline Maillard, Erwan Bezard, Paul Perez, Anne Pavy-Le Traon, Olivier Rascol, Alexandra Foubert-Samier, François Tison, Wassilios G. Meissner
Neurobiology of Disease. 2014-07-01
10.1016/j.nbd.2014.03.021

Widespread Monoaminergic Dysregulation of Both Motor and Non-Motor Circuits in Parkinsonism and Dyskinesia.
Michel Engeln, Philippe De Deurwaerdère, Qin Li, Erwan Bezard, Pierre-Olivier Fernagut
Cereb. Cortex. 2014-04-25
10.1093/cercor/bhu076

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.
Ariadna Recasens, Benjamin Dehay, Jordi Bové, Iria Carballo-Carbajal, Sandra Dovero, Ana Pérez-Villalba, Pierre-Olivier Fernagut, Javier Blesa, Annabelle Parent, Celine Perier, Isabel Fariñas, José A. Obeso, Erwan Bezard, Miquel Vila
Ann Neurol.. 2014-02-18
10.1002/ana.24066

Immediate-early gene expression in structures outside the basal ganglia is associated to l-DOPA-induced dyskinesia.
Matthieu F. Bastide, Sandra Dovero, Giselle Charron, Gregory Porras, Christian E. Gross, Pierre-Olivier Fernagut, Erwan Bézard
Neurobiology of Disease. 2014-02-01
10.1016/j.nbd.2013.09.020

Breathing variability and brainstem serotonergic loss in a genetic model of multiple system atrophy.
Olivier Flabeau, Wassilios G. Meissner, Annaig Ozier, Patrick Berger, François Tison, Pierre-Olivier Fernagut
Mov Disord.. 2014-01-17
10.1002/mds.25804

Premotor parkinsonism models.
Erwan Bezard, Pierre-Olivier Fernagut
Parkinsonism & Related Disorders. 2014-01-01
10.1016/s1353-8020(13)70007-5

Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy
P.O. Fernagut, W.G. Meissner, M. Biran, M. Fantin, F. Bassil, J.M. Franconi, F. Tison
Synapse. 2013-11-15
10.1002/syn.21719

Levodopa gains psychostimulant-like properties after nigral dopaminergic loss.
Michel Engeln, Stefania Fasano, Serge H. Ahmed, Martine Cador, Veerle Baekelandt, Erwan Bezard, Pierre-Olivier Fernagut
Ann Neurol.. 2013-07-01
10.1002/ana.23881

Reinforcing properties of Pramipexole in normal and parkinsonian rats.
Michel Engeln, Serge H. Ahmed, Caroline Vouillac, François Tison, Erwan Bezard, Pierre-Olivier Fernagut
Neurobiology of Disease. 2013-01-01
10.1016/j.nbd.2012.08.005

Animal models of multiple system atrophy.
P.-O. Fernagut, F. Tison
Neuroscience. 2012-06-01
10.1016/j.neuroscience.2011.09.044

Links between glucocerebrosidase and alpha-synuclein revealed
Pierre‐Olivier Fernagut
Movement Disorders. 2011-10-01
10.1002/mds.23985

Ambiguous mechanisms of dysphagia in multiple system atrophy
Pierre-Olivier Fernagut, Anne Vital, Marie-Hélène Canron, François Tison, Wassilios G. Meissner
Brain. 2011-08-08
10.1093/brain/awr185

NR2B subunit blockade does not affect motor symptoms induced by 3-nitropropionic acid
Martina Fantin, Michele Morari, François Tison, Pierre-Olivier Fernagut
Neurological Research. 2011-05-01
10.1179/1743132810y.0000000002

Protein aggregation in the aging retina.
François Leger, Pierre-Olivier Fernagut, Marie-Hélène Canron, Sandy Léoni, Claude Vital, François Tison, Erwan Bezard, Anne Vital
J Neuropathol Exp Neurol. 2011-01-01
10.1097/nen.0b013e31820376cc

Metabolic activity of the subthalamic nucleus in a primate model of L-dopa-unresponsive parkinsonism.
Pierre-Olivier Fernagut, Quentin Barraud, Erwan Bezard, Imad Ghorayeb, Francois Tison
Neurological Research. 2010-12-01
10.1179/016164110x12807570509934

Dopamine transporter binding is unaffected by L-DOPA administration in normal and MPTP-treated monkeys.
Pierre-Olivier Fernagut, Qin Li, Sandra Dovero, Piu Chan, Tao Wu, Paula Ravenscroft, Michael Hill, Zhenwen Chen, Erwan Bezard
PLoS ONE. 2010-11-22
10.1371/journal.pone.0014053

Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders.
Valerie Voon, Pierre-Olivier Fernagut, Jeff Wickens, Christelle Baunez, Manuel Rodriguez, Nancy Pavon, Jorge L Juncos, José A Obeso, Erwan Bezard
The Lancet Neurology. 2009-12-01
10.1016/s1474-4422(09)70287-x

The nigrostriatal pathway in Creutzfeldt-Jakob disease.
Anne Vital, Pierre-Olivier Fernagut, Marie-Hélène Canron, Julien Joux, Erwan Bezard, Marie-Laure Martin-Negrier, Claude Vital, François Tison
J Neuropathol Exp Neurol. 2009-07-01
10.1097/nen.0b013e3181abdae8

Ziram Causes Dopaminergic Cell Damage by Inhibiting E1 Ligase of the Proteasome
Arthur P. Chou, Nigel Maidment, Rebecka Klintenberg, John E. Casida, Sharon Li, Arthur G. Fitzmaurice, Pierre-Olivier Fernagut, Farzad Mortazavi, Marie-Francoise Chesselet, Jeff M. Bronstein
Journal of Biological Chemistry. 2008-12-01
10.1074/jbc.m802210200

Behavioral and histopathological consequences of paraquat intoxication in mice: Effects of α-synuclein over-expression
P.O. Fernagut, C.B. Hutson, S.M. Fleming, N.A. Tetreaut, J. Salcedo, E. Masliah, M.F. Chesselet
Synapse. 2007-09-18
10.1002/syn.20456

Effects of riluzole on combined MPTP + 3-nitropropionic acid-induced mild to moderate striatonigral degeneration in mice
E. Diguet, P.-O. Fernagut, C. Scherfler, G. Wenning, F. Tison
J Neural Transm. 2004-10-22
10.1007/s00702-004-0206-z

Deleterious effects of minocycline in animal models of Parkinson's disease and Huntington's disease.
Elsa Diguet, Pierre-Olivier Fernagut, Xing Wei, Yansheng Du, Richard Rouland, Christian Gross, Erwan Bezard, François Tison
European Journal of Neuroscience. 2004-06-01
10.1111/j.0953-816x.2004.03372.x

Experimental basis for the putative role of GluR6/kainate glutamate receptor subunit in Huntington's disease natural history.
Elsa Diguet, Pierre-Olivier Fernagut, Elisabeth Normand, Laurie Centelles, Christophe Mulle, François Tison
Neurobiology of Disease. 2004-04-01
10.1016/j.nbd.2003.12.010

Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy)
Zoe Puschban, Pierre-Olivier Fernagut, Emmanuel Brouillet, Fran�ois Tison, Markus Reindl, Kurt A. Jellinger, Werner Poewe, Gregor K. Wenning, Nadia Stefanova
Acta Neuropathologica. 2003-08-01
10.1007/s00401-003-0717-y

Motor behaviour deficits and their histopathological and functional correlates in the nigrostriatal system of dopamine transporter knockout mice
P.-O Fernagut, S Chalon, E Diguet, D Guilloteau, F Tison, M Jaber
Neuroscience. 2003-02-01
10.1016/s0306-4522(02)00778-9

A ‘single toxin–double lesion’ rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis
I Ghorayeb, P.O Fernagut, L Hervier, B Labattu, B Bioulac, F Tison
Neuroscience. 2002-12-01
10.1016/s0306-4522(02)00401-3

Dystonia is predictive of subsequent altered dopaminergic responsiveness in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine+3-nitropropionic acid model of striatonigral degeneration in monkeys
I Ghorayeb, P.O Fernagut, N Stefanova, G.K Wenning, B Bioulac, F Tison
Neuroscience Letters. 2002-12-01
10.1016/s0304-3940(02)01137-0

Dystonia is predictive of subsequent altered dopaminergic responsiveness in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + 3-nitropropionic acid model of striatonigral degeneration in monkeys
I Ghorayeb, P.O Fernagut, N Stefanova, G.K Wenning, B Bioulac, F Tison
Neuroscience Letters. 2002-12-01
10.1016/s0304-3940(02)01137-0

A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: A motor behavioural analysis
I Ghorayeb, P.O Fernagut, L Hervier, B Labattu, B Bioulac, F Tison
Neuroscience. 2002-12-01
10.1016/s0306-4522(02)00401-3

Subacute systemic 3-nitropropionic acid intoxication induces a distinct motor disorder in adult C57Bl/6 mice: behavioural and histopathological characterisation
P.O. Fernagut, E. Diguet, N. Stefanova, M. Biran, G.K. Wenning, P. Canioni, B. Bioulac, F. Tison
Neuroscience. 2002-11-01
10.1016/s0306-4522(02)00205-1

Dopamine transporter knock‐out mice are hypersensitive to 3‐nitropropionic acid‐induced striatal damage
Pierre‐O. Fernagut, Elsa Diguet, Mohamed Jaber, Bernard Bioulac, François Tison
European Journal of Neuroscience. 2002-06-01
10.1046/j.1460-9568.2002.02047.x

A simple method to measure stride length as an index of nigrostriatal dysfunction in mice
Pierre O Fernagut, Elsa Diguet, Bertrand Labattu, François Tison
Journal of Neuroscience Methods. 2002-01-01
10.1016/s0165-0270(01)00485-x

Simultaneous Intrastriatal 6-Hydroxydopamine and Quinolinic Acid Injection: A Model of Early-Stage Striatonigral Degeneration
Imad Ghorayeb, Zoe Puschban, Pierre O. Fernagut, Christoph Scherfler, Richard Rouland, Gregor K. Wenning, François Tison
Experimental Neurology. 2001-01-01
10.1006/exnr.2000.7535

Toward a primate model of L-dopa-unresponsive parkinsonism mimicking striatonigral degeneration.
Imad Ghorayeb, Pierre O. Fernagut, Incarnation Aubert, Erwan Bezard, Werner Poewe, Gregor K. Wenning, François Tison
Mov. Disord.. 2000-05-01
10.1002/1531-8257(200005)15:33.0.co;2-c