{"id":491,"date":"2025-03-08T10:16:15","date_gmt":"2025-03-08T09:16:15","guid":{"rendered":"https:\/\/imn-prod.onlinecreation.pro\/?post_type=buni_events&p=491"},"modified":"2025-03-18T16:00:57","modified_gmt":"2025-03-18T15:00:57","slug":"conference-ibio-rri-impact-michel-thiebaut-de-schotten","status":"publish","type":"buni_events","link":"https:\/\/imn.u-bordeaux.fr\/fr\/events\/conference-ibio-rri-impact-michel-thiebaut-de-schotten\/","title":{"rendered":"Conf\u00e9rence IBIO\/RRI IMPACT – Michel Thiebaut de Schotten"},"content":{"rendered":"
\n
\n

Venue: IBIO<\/strong><\/p>\n

Also on zoom :\u00a0 https:\/\/u-bordeaux-fr.zoom.us\/j\/83115534343?pwd=lF0rKLx94A9FOZcA2PTL1YIiW4EgSQ.1<\/a><\/span><\/span><\/span><\/span><\/p>\n<\/div>\n

\n<\/div>\n
\n

Michel Thiebaut de Schotten<\/a><\/strong>
\nTeam leader – IMN<\/p>\n

Title<\/h3>\n

Deep Learning for Quantitative Analysis of Brain MRI<\/em><\/p>\n

Abstract<\/span><\/span><\/h3>\n
Mitochondrial oxidative phosphorylation (OxPhos) powers brain activity1<\/a><\/span><\/span><\/span><\/span>,2<\/a><\/span><\/span><\/span><\/span><\/sup>, and mitochondrial defects are linked to neurodegenerative and neuropsychiatric disorders3<\/a><\/span><\/span><\/span><\/span>,4<\/a><\/span><\/span><\/span><\/span><\/sup>, underscoring the need to define the brain\u2019s molecular energetic landscape5<\/a><\/span><\/span><\/span><\/span>\u201310<\/a><\/span><\/span><\/span><\/span><\/sup>. To bridge the cognitive neuroscience and cell biology scale gap, we developed a physical voxelization approach to partition a frozen human coronal hemisphere section into 703 voxels comparable to neuroimaging resolution (3\u00d73\u00d73 mm). In each cortical and subcortical brain voxel, we profiled mitochondrial phenotypes including OxPhos enzyme activities, mitochondrial DNA and volume density, and mitochondria-specific respiratory capacity. We show that the human brain contains a diversity of mitochondrial phenotypes driven by both topology and cell types. Compared to white matter, grey matter contains >50% more mitochondria. We show that the more abundant grey matter mitochondria also are biochemically optimized for energy transformation, particularly among recently evolved cortical brain regions. Scaling these data to the whole brain, we created a backward linear regression model integrating several neuroimaging modalities11<\/a><\/span><\/span><\/span><\/span><\/sup>, thereby generating a brain-wide map of mitochondrial distribution and specialization that predicts mitochondrial characteristics in an independent brain region of the same donor brain. This new approach and the resulting MitoBrainMap of mitochondrial phenotypes provide a foundation for exploring the molecular energetic landscape that enables normal brain functions, relating it to neuroimaging data, and defining the subcellular basis for regionalized brain processes relevant to neuropsychiatric and neurodegenerative disorders.<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Deep Learning for Quantitative Analysis of Brain MRI \/\/ Venue: IBIO<\/p>\n","protected":false},"template":"","categories":[17],"class_list":["post-491","buni_events","type-buni_events","status-publish","hentry","category-agenda-fr"],"_links":{"self":[{"href":"https:\/\/imn.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/buni_events\/491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/imn.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/buni_events"}],"about":[{"href":"https:\/\/imn.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/types\/buni_events"}],"wp:attachment":[{"href":"https:\/\/imn.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/media?parent=491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/imn.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/categories?post=491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}