Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges
Advanced Science. 2026-01-25
10.1002/advs.202523809

High-accuracy electrode implantation in deep brain structures using multi-camera neuronavigation in non-human primates
Ankur Gupta, Adrien Boissenin, Nikolaos Vardalakis, Mathieu Taillade, Hugues Orignac, Nathalie Biendon, Sandra Dovero, Tho-Hai Nguyen, Amirouche Sadoun, Fabien B Wagner
J. Neural Eng.. 2025-10-14
10.1088/1741-2552/ae135b

Intra-putaminal muscarinic receptor agonist infusion induces a dystonic phenotype in non-human primate
Bastien Ribot, Edouard Courtin, Marc Deffains, Jérôme Aupy, Sandra Dovero, Nathalie Biendon, Tho Hai N’Guyen, Hugues Orignac, Pierre Burbaud, Dominique Guehl
Brain. 2025-07-24
10.1093/brain/awaf271

Differential Pathological Dynamics triggered by distinct Parkinson patient-derived α-synuclein extracts in non-human primates
R. Kinet, M. Bourdenx, S. Dovero, M. Darricau, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, I. Trigo-Damas, S. Bohic, M. Morari, E. Doudnikoff, M. Goikoetxea, S. Claverol, C. Tokarski, N. Kruse, B. Mollenhauer, C. Estrada, N. Garcia-Carrillo, M. T. Herrero, M. Vila, J. A. Obeso, E. Bezard, B. Dehay
Sci. Adv.. 2025-06-20
10.1126/sciadv.adu6050

Distinct neuronal processes in the ventromedial prefrontal cortex mediate changes in attention load and nicotine pro-cognitive effects in male rats
Caroline Vouillac-Mendoza, Nathalie Biendon, Sandra Dovero, Karine Guillem
Front. Neural Circuits. 2025-03-07
10.3389/fncir.2025.1540975

Nigral ATP13A2 depletion induces Parkinson’s disease-related neurodegeneration in a pilot study in non-human primates
Joanna Sikora, Sandra Dovero, Rémi Kinet, Marie-Laure Arotcarena, Sylvain Bohic, Erwan Bezard, Pierre-Olivier Fernagut, Benjamin Dehay
npj Parkinsons Dis.. 2024-08-01
10.1038/s41531-024-00757-4

Reconsidering α-Synuclein inclusion pathology in neurons, mice, and humans with an antibody sensing NAC engagement during α-Synuclein amyloid conversion
Francesca De Giorgi, Ænora Letourneur, Marianna Kashyrina, Federica Zinghirino, Sandra Dovero, Nathalie Dutheil, Leslie-Ann Largitte, Marie-Laure Arotçarena, Erwan Bezard, Marie-Hélène Canron, Wassilios Meissner, Francesco De Nuccio, Dario Domenico Lofrumento, Florent Laferrière, François Ichas
Preprint - Research Square. 2024-02-07
10.21203/rs.3.rs-3921168/v1

Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Morgane Darricau, Gregory Porras, Marie-Laure Thiolat, Inés Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, María Trinidad Herrero, Miquel Vila, José A. Obeso, Erwan Bezard, Benjamin Dehay
npj Parkinsons Dis.. 2023-09-19
10.1038/s41531-023-00579-w

Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates
Fayard Audrey, Fenyi Alexis, Lavisse Sonia, Dovero Sandra, Bousset Luc, Tracy Bellande, Lecourtois Sophie, Jouy Christophe, Guillermier Martine, Jan Caroline, Gipchtein Pauline, Dehay Benjamin, Bezard Erwan, Melki Ronald, Hantraye Philippe, Aron Badin Romina
Neurobiology of Disease. 2023-03-01
10.1016/j.nbd.2023.106086

Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology
Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Ines Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, Michele Morari, Wassilios G Meissner, María Trinidad Herrero, Miquel Vila, Jose A Obeso, Erwan Bezard, Benjamin Dehay
Brain. 2022-03-14
10.1093/brain/awab374

In vivo susceptibility to energy failure parkinsonism and LRRK2 kinase activity
Salvatore Novello, Daniela Mercatelli, Federica Albanese, Chiara Domenicale, Alberto Brugnoli, Elisabetta D'Aversa, Silvia Vantaggiato, Sandra Dovero, Valentina Murtaj, Luca Presotto, Monica Borgatti, Derya R. Shimshek, Erwan Bezard, Rosa Maria Moresco, Sara Belloli, Michele Morari
Neurobiology of Disease. 2022-01-01
10.1016/j.nbd.2021.105579

Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques
Marie-Laure Arotcarena, Sandra Dovero, Nathalie Biendon, Nathalie Dutheil, Vincent Planche, Erwan Bezard, Benjamin Dehay
Front. Bioeng. Biotechnol.. 2021-11-15
10.3389/fbioe.2021.762209

Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE
Xiuping Sun, Xuan Yu, Ling Zhang, Wenjie Zhao, Manshi Wang, Yu Zhang, Xianglei Li, Ran Gao, Ludivine S. Breger, Sandra Dovero, Gregory Porras, Pierre-Olivier Fernagut, Benjamin Dehay, Erwan Bezard, Chuan Qin
Heliyon. 2021-02-01
10.1016/j.heliyon.2021.e06302

Evaluation of blood flow as a route for propagation in experimental synucleinopathy
Xuan Yu, Marine Persillet, Ling Zhang, Yu Zhang, Sun Xiuping, Xianglei Li, Gao Ran, Ludivine S. Breger, Sandra Dovero, Gregory Porras, Benjamin Dehay, Erwan Bezard, Chuan Qin
Neurobiology of Disease. 2021-01-01
10.1016/j.nbd.2021.105255

Acute Striato-Cortical Synchronization Induces Focal Motor Seizures in Primates
Jerome Aupy, Bastien Ribot, Sandra Dovero, Nathalie Biendon, Tho-Hai Nguyen, Gregory Porras, Marc Deffains, Dominique Guehl, Pierre Burbaud
Cerebral Cortex. 2020-08-08
10.1093/cercor/bhaa212

Ablation of the tail of the ventral tegmental area compensates symptoms in an experimental model of Parkinson's disease.
Fanny Faivre, María-José Sánchez-Catalán, Sandra Dovero, Simone Bido, Anil Joshi, Erwan Bezard, Michel Barrot
Neurobiology of Disease. 2020-06-01
10.1016/j.nbd.2020.104818

In vivo electrophysiological validation of DREADD-based modulation of pallidal neurons in the non-human primate.
Marc Deffains, Tho Haï Nguyen, Hugues Orignac, Nathalie Biendon, Sandra Dovero, Erwan Bezard, Thomas Boraud
Eur J Neurosci. 2020-05-11
10.1111/ejn.14746

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates
M. Bourdenx, A. Nioche, S. Dovero, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, N. P. Rougier, A. Prigent, P. Aubert, S. Bohic, C. Sandt, F. Laferrière, E. Doudnikoff, N. Kruse, B. Mollenhauer, S. Novello, M. Morari, T. Leste-Lasserre, I. Trigo Damas, M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N. N. Vaikath, O. M. A. El-Agnaf, M. T. Herrero, P. Derkinderen, M. Vila, J. A. Obeso, B. Dehay, E. Bezard
Sci. Adv.. 2020-05-01
10.1126/sciadv.aaz9165

Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates
Marie-Laure Arotcarena, Sandra Dovero, Alice Prigent, Mathieu Bourdenx, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Maddalena Tasselli, Philippe Aubert, Niels Kruse, Brit Mollenhauer, Ines Trigo Damas, Cristina Estrada, Nuria Garcia-Carrillo, Nishant N Vaikath, Omar M A El-Agnaf, Maria Trinidad Herrero, Miquel Vila, Jose A Obeso, Pascal Derkinderen, Benjamin Dehay, Erwan Bezard
Brain. 2020-05-01
10.1093/brain/awaa096

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates
M. Bourdenx, A. Nioche, S. Dovero, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, N. P. Rougier, A. Prigent, P. Aubert, S. Bohic, C. Sandt, F. Laferrière, E. Doudnikoff, N. Kruse, B. Mollenhauer, S. Novello, M. Morari, T. Leste-Lasserre, I. Trigo Damas, M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N. N. Vaikath, O. M. A. El-Agnaf, M. Trinidad Herrero, P. Derkinderen, M. Vila, J. A. Obeso, B. Dehay, E. Bezard
. 2019-10-31
10.1101/825216

Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
Marie-Laure Arotcarena, Mathieu Bourdenx, Nathalie Dutheil, Marie-Laure Thiolat, Evelyne Doudnikoff, Sandra Dovero, Andrea Ballabio, Pierre-Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard, Benjamin Dehay
JCI Insight. 2019-08-22
10.1172/jci.insight.129719

Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease.
Carl Rosenblad, Qin Li, Elsa Y. Pioli, Sandra Dovero, André SLM Antunes, Leticia Agúndez, Martino Bardelli, R. Michael Linden, Els Henckaerts, Anders Björklund, Erwan Bezard, Tomas Björklund
Brain. 2019-06-26
10.1093/brain/awz176

G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice.
Salvatore Novello, Ludovico Arcuri, Sandra Dovero, Nathalie Dutheil, Derya R. Shimshek, Erwan Bezard, Michele Morari
Neurobiology of Disease. 2018-12-01
10.1016/j.nbd.2018.08.018

Systemic Gene Delivery by Single-Dose Intracardiac Administration of scAAV2/9 and scAAV2/rh10 Variants in Newborn Rats.
Lucie Chansel-Debordeaux, Mathieu Bourdenx, Nathalie Dutheil, Sandra Dovero, Marie-Helene Canron, Clement Jimenez, Erwan Bezard, Benjamin Dehay
Human Gene Therapy Methods. 2018-08-01
10.1089/hgtb.2017.192.r3

In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson's disease.
L Chansel-Debordeaux, M Bourdenx, S Dovero, V Grouthier, N Dutheil, A Espana, L Groc, C Jimenez, E Bezard, B Dehay
Gene Ther. 2017-11-16
10.1038/gt.2017.84

Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegeneration.
Federico N. Soria, Michel Engeln, Marta Martinez-Vicente, Christelle Glangetas, María José López-González, Sandra Dovero, Benjamin Dehay, Elisabeth Normand, Miquel Vila, Alexandre Favereaux, François Georges, Christophe Lo Bianco, Erwan Bezard, Pierre-Olivier Fernagut
Human Molecular Genetics. 2017-05-17
10.1093/hmg/ddx120

Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model.
Mathieu Bourdenx, Sandra Dovero, Marie-Laure Thiolat, Erwan Bezard, Benjamin Dehay
Sci Rep. 2017-04-04
10.1038/srep45831

Early prenatal exposure to MPTP does not affect nigrostrial neurons in macaque monkey.
Mathieu Bourdenx, Sandra Dovero, Philippe De DeurwAerdère, Qin Li, Erwan Bezard
Synapse. 2015-12-04
10.1002/syn.21876

Unexpected toxicity of very low dose MPTP in mice: A clue to the etiology of Parkinson's disease?
Sandra Dovero, Christian Gross, Erwan Bezard
Synapse. 2015-12-01
10.1002/syn.21875

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.
Mathieu Bourdenx, Sandra Dovero, Michel Engeln, Simone Bido, Matthieu F. Bastide, Nathalie Dutheil, Isabel Vollenweider, Laetitia Baud, Camille Piron, Virginie Grouthier, Thomas Boraud, Grégory Porras, Qin Li, Veerle Baekelandt, Dieter Scheller, Anne Michel, Pierre-Olivier Fernagut, François Georges, Grégoire Courtine, Erwan Bezard, Benjamin Dehay
acta neuropathol commun. 2015-07-25
10.1186/s40478-015-0222-2

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.
Ariadna Recasens, Benjamin Dehay, Jordi Bové, Iria Carballo-Carbajal, Sandra Dovero, Ana Pérez-Villalba, Pierre-Olivier Fernagut, Javier Blesa, Annabelle Parent, Celine Perier, Isabel Fariñas, José A. Obeso, Erwan Bezard, Miquel Vila
Ann Neurol.. 2014-02-18
10.1002/ana.24066

Immediate-early gene expression in structures outside the basal ganglia is associated to l-DOPA-induced dyskinesia.
Matthieu F. Bastide, Sandra Dovero, Giselle Charron, Gregory Porras, Christian E. Gross, Pierre-Olivier Fernagut, Erwan Bézard
Neurobiology of Disease. 2014-02-01
10.1016/j.nbd.2013.09.020

Coordinated reset has sustained aftereffects in Parkinsonian monkeys.
Peter A. Tass, Li Qin, Christian Hauptmann, Sandra Dovero, Erwan Bezard, Thomas Boraud, Wassilios G. Meissner
Ann Neurol.. 2012-11-01
10.1002/ana.23663

PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking
Gregory Porras, Amandine Berthet, Benjamin Dehay, Qin Li, Laurent Ladepeche, Elisabeth Normand, Sandra Dovero, Audrey Martinez, Evelyne Doudnikoff, Marie-Laure Martin-Négrier, Qin Chuan, Bertrand Bloch, Daniel Choquet, Eric Boué-Grabot, Laurent Groc, Erwan Bezard
J. Clin. Invest.. 2012-10-08
10.1172/JCI59426

The associative and limbic thalamus in the pathophysiology of obsessive-compulsive disorder: An experimental study in the monkey
J Y Rotge, B Aouizerate, V Amestoy, V Lambrecq, N Langbour, T H Nguyen, S Dovero, L Cardoit, J Tignol, B Bioulac, P Burbaud, D Guehl
Transl Psychiatry. 2012-09-01
10.1038/tp.2012.88

Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.
Benjamin Dehay, Deniz Dalkara, Sandra Dovero, Qin Li, Erwan Bezard
Sci Rep. 2012-02-09
10.1038/srep00253

The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research
Peter A. Tass, Li Qin, Christian Hauptmann, Sandra Dovero, Erwan Bezard, Thomas Boraud, Wassilios G. Meissner
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2011-08-01
10.1109/IEMBS.2011.6090148

Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia.
S. Fasano, E. Bezard, A. D'Antoni, V. Francardo, M. Indrigo, L. Qin, S. Dovero, M. Cerovic, M. A. Cenci, R. Brambilla
Proceedings of the National Academy of Sciences. 2010-11-29
10.1073/pnas.1012071107

Dopamine transporter binding is unaffected by L-DOPA administration in normal and MPTP-treated monkeys.
Pierre-Olivier Fernagut, Qin Li, Sandra Dovero, Piu Chan, Tao Wu, Paula Ravenscroft, Michael Hill, Zhenwen Chen, Erwan Bezard
PLoS ONE. 2010-11-22
10.1371/journal.pone.0014053

Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia.
Daniella Rylander, Martin Parent, Sean S. O'Sullivan, Sandra Dovero, Andrew J. Lees, Erwan Bezard, Laurent Descarries, M. Angela Cenci
Ann Neurol.. 2010-09-29
10.1002/ana.22097

Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia.
Emanuela Santini, Veronique Sgambato-Faure, Qin Li, Marc Savasta, Sandra Dovero, Gilberto Fisone, Erwan Bezard
PLoS ONE. 2010-08-23
10.1371/journal.pone.0012322

Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease.
M. R. Ahmed, A. Berthet, E. Bychkov, G. Porras, Q. Li, B. H. Bioulac, Y. T. Carl, B. Bloch, S. Kook, I. Aubert, S. Dovero, E. Doudnikoff, V. V. Gurevich, E. V. Gurevich, E. Bezard
Science Translational Medicine. 2010-04-21
10.1126/scitranslmed.3000664

Lentiviral overexpression of GRK6 alleviates L-Dopa-induced dyskinesia in experimental parkinson's disease
M. R. Ahmed, A. Berthet, E. Bychkov, G. Porras, Q. Li, B. H. Bioulac, Y. T. Carl, B. Bloch, S. Kook, I. Aubert, S. Dovero, E. Doudnikoff, V. V. Gurevich, E. V. Gurevich, E. Bezard
Science Translational Medicine. 2010-04-21
10.1126/scitranslmed.3000664

IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP.
Agnès Nadjar, Olivier Berton, Shuhong Guo, Patricia Leneuve, Sandra Dovero, Elsa Diguet, François Tison, Baolu Zhao, Martin Holzenberger, Erwan Bezard
Neurobiology of Aging. 2009-12-01
10.1016/j.neurobiolaging.2008.02.009

Enhanced preproenkephalin-B-derived opioid transmission in striatum and subthalamic nucleus converges upon globus pallidus internalis in L-3,4-dihydroxyphenylalanine-induced dyskinesia.
Incarnation Aubert, Céline Guigoni, Qin Li, Sandra Dovero, Bernard H. Bioulac, Christian E. Gross, Alan R. Crossman, Bertrand Bloch, Erwan Bezard
Biological Psychiatry. 2007-04-01
10.1016/j.biopsych.2006.06.038

Levodopa-induced dyskinesia in MPTP-treated macaques is not dependent on the extent and pattern of nigrostrial lesioning.
Céline Guigoni, Sandra Dovero, Incarnation Aubert, Qin Li, Bernard H. Bioulac, Bertrand Bloch, Eugenia V. Gurevich, Christian E. Gross, Erwan Bezard
European Journal of Neuroscience. 2005-07-01
10.1111/j.1460-9568.2005.04196.x

Involvement of sensorimotor, limbic, and associative basal ganglia domains in L-3,4-dihydroxyphenylalanine-induced dyskinesia
C. Guigoni
Journal of Neuroscience. 2005-02-23
10.1523/JNEUROSCI.5059-04.2005

Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia.
Incarnation Aubert, Céline Guigoni, Kerstin Håkansson, Qin Li, Sandra Dovero, Nicole Barthe, Bernard H. Bioulac, Christian E. Gross, Gilberto Fisone, Bertrand Bloch, Erwan Bezard
Ann Neurol.. 2004-10-27
10.1002/ana.20296

Asymmetrically lesioned mesencephalon in healthy rodents: call for caution.
Elsa Y. Pioli, Sandra Dovero, Bernard H. Bioulac, Christian E. Gross, Erwan Bezard
Brain Research. 2004-10-01
10.1016/j.brainres.2004.07.014

Compensatory regulation of striatal neuropeptide gene expression occurs before changes in metabolic activity of basal ganglia nuclei
Wassilios Meissner, Sandra Dovero, Bernard Bioulac, Christian E. Gross, Erwan Bezard
Neurobiology of Disease. 2003-06-01
10.1016/S0969-9961(03)00011-1

Compensatory regulation of striatal neuropeptide gene expression occurs before changes in metabolic activity of basal ganglia nuclei.
Wassilios Meissner, Sandra Dovero, Bernard Bioulac, Christian E. Gross, Erwan Bezard
Neurobiology of Disease. 2003-06-01
10.1016/s0969-9961(03)00011-1

Pattern of levodopa-induced striatal changes is different in normal and MPTP-lesioned mice.
Christian E. Gross, Paula Ravenscroft, Sandra Dovero, Mohamed Jaber, Bernard Bioulac, Erwan Bezard
Journal of Neurochemistry. 2003-03-01
10.1046/j.1471-4159.2003.01600.x

Pattern of levodopa-induced striatal changes is different in normal and MPTP-lesioned mice.
Christian E. Gross, Paula Ravenscroft, Sandra Dovero, Mohamed Jaber, Bernard Bioulac, Erwan Bezard
Journal of Neurochemistry. 2003-03-01
10.1046/j.1471-4159.2003.01600.x

Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice
Erwan Bezard, Sra Dovero, Christelle Imbert, Thomas Boraud, Christian E. Gross
Synapse. 2000-01-01
10.1002/1098-2396(20001201)38:33.0.CO;2-A

Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter.
Erwan Bezard, Christian E. Gross, Marie-Christine Fournier, Sandra Dovero, Bertrand Bloch, Mohamed Jaber
Experimental Neurology. 1999-02-01
10.1006/exnr.1998.6995

Towards a dynamic approach of experimental parkinsonism
Erwan Bezard, Thomas Boraud, Christelle Imbert, Sandra Dovero Bernard Bioulac, Christian E. Gross
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1998-11-01
10.1016/S0278-5846(98)00072-4

Kinetics of nigral degeneration in a chronic model of MPTP-treated mice
Erwan Bezard, Sandra Dovero, Bernard Bioulac, Christian E Gross
Neuroscience Letters. 1997-09-01
10.1016/S0304-3940(97)00663-0

Kinetics of nigral degeneration in a chronic model of MPTP-treated mice.
Erwan Bezard, Sandra Dovero, Bernard Bioulac, Christian E Gross
Neuroscience Letters. 1997-09-01
10.1016/s0304-3940(97)00663-0